Gene Therapy Using Adenovirus-Mediated Full-length Anti-HER-2 Antibody for HER-2 Overexpression Cancers

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Gene therapy using adenovirus-mediated full-length anti-HER-2 antibody for HER-2 overexpression cancers.

PURPOSE Therapeutic monoclonal antibody is increasingly applied in many clinical applications, although complicated technologies and high cost still limit their wide applications. To obtain the sustained serum antibody concentration with one single injection and lower the cost of antibody protein therapy, an adenovirus-mediated full-length antibody gene therapy was developed. EXPERIMENTAL DES...

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ژورنال

عنوان ژورنال: Clinical Cancer Research

سال: 2006

ISSN: 1078-0432,1557-3265

DOI: 10.1158/1078-0432.ccr-06-0746